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Director:Chee-Jen Chang Ph.D.
Position:Distinguished Professor
TEL(03)211-8800 #3577
Education:Ph.D. Department of Statistics, University Iowa, Iowa City, Iowa.

Major Research Area
  1. Statistical modeling in pharmacoeconomics and outcome research.
  2. Strategy and methodology approaches and statistical data analysis to clinical trials, clinical epidemiology research, and basic science experiments.
  3. Strategical planning, study design and data analysis in pharmacoeconomics.
  4. Statistical methodology development in bridging studies.
  5. Data mining technique applied to the biomedical data sets.
  6. Data analysis in microarray data and proteomics.
  7. BI in clinical informatics.
  8. Data analysis IT tool in clinical trials.

Professional Appointment:
  1. Professor, Graduate Institute of Clinical Medical Science, Chang Gung University.(2005~present)
  2. Jointly Appointed Professor, Department of Biomedical Sciences, Chang Gung University(2018~present)
  3.  Director, Clinical Informatics and Medical Statistics Research Center, Chang Gung University.(2009~present)
  4. Director, Research Services Center for Health Information, Chang Gung University.(2013~present)
  5. Adjunct Professor, Graduate Institute of Clinical Medicine and Graduate Institute of Clinical Pharmacy, School of Medicine, National Taiwan University.(2005~present)
  6. Adjunct Professor, Graduate Institute of Medical Mechatronics, Chang Gung University.(2007~present)
  7.  Executive Director, Taiwan Society for Pharmacoeconomics and Outcome Research (TaSPOR)(2018~present)



  1. International Society for Pharmacoeconomics and Outcomes Research Asia Consortium, Chair-elect, Advisory Committee.(2017-2019)
  2. Association of Varicose Veins With Incident Venous Thromboembolism and Peripheral Artery Disease (2018/02 JAMA: The Journal of the American Medical Association,2016 IF: 44.405, Rank: 3/155)

Publication (In the nearst 5 years): 

  1. Yi-Ming Weng, Chip-Jin Ng, Chen-June Seak, Cheng-Yu Chien, Kuan-Fu Chen,Jr-Rung Lin, Chee-Jen Chang. One-year survival rate and healthcare costs after cardiac arrest in Taiwan, 2006–2012. PLOS ONE 2018, 13(5):e0196687
  2. Chuang-Wei Wang, Lan-Yan Yang, Chun-Bing Chen, Hsin-Chun Ho, Shuen-Iu Hung, Chih-Hsun Yang, Chee-Jen Chang, Shih-Chi Su, Rosaline Chung-Yee Hui, See-Wen Chin, Li-Fang Huang, Yang Yu-Wei Lin, Wei-Yang Chang, Wen-Lang Fan, Chin-Yi Yang, Ji-Chen Ho, Ya-Ching Chang, Chun-Wei Lu, Wen-Hung Chung, the Taiwan Severe Cutaneous Adverse Reaction (TSCAR) Consortium. Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions. J Clin Invest. 2018, 128(3):985-996
  3. Dong-Yi Chen, Chen-Yu Li, Ming-Jer Hsieh, Chun-Chi Chen, I-Chang Hsieh, Tien-Hsing Chen, Shao-Wei Chen, Chao-Yung Wang, Shang-Hung Chang, Cheng-Hung Lee, Ming-Lung Tsai, Ming-Yun Ho, Jih-Kai Yeh, Chee-Jen Chang, Ming-Shien Wen. Predictors of subsequent myocardial infarction, stroke, and death in stable post-myocardial infarction patients: A nationwide cohort study. European Heart Journal: Acute Cardiovascular Care 2017 (Accepted)
  4. Chang-Teng Wu, Chyi-Liang Chen, Hao-Yuan Lee, Chee-Jen Chang, Pi-Yu Liu, Chin-Ying Li, Ming-Ying Liu, Chien-Hsisung Liu. Decreased antimicrobial resistance and defined daily doses after implementation of a clinical culture-guided antimicrobial stewardship program in a local hospital. Journal of Microbiology, Immunology and Infection 2017, 50(6):846-856
  5. Chung-Yen Lu, Hsin-Chia Huang, Hen-Hong Chang, Tsung-Hsien Yang, Chee-Jen Chang, Su-Wei Chang, Pei-Chun Chen. Acupuncture therapy and incidence of depression after stroke. Stroke 2017, 48(11):1682-1684
  6. Ying-Chang Tung, Yu-Chang Huang, Lung-Sheng, Chee-Jen Chang, Pao-Hsien Chu. Medication compliance and clinical outcomes of fixed- dose combinations vs free combinations of an angiotensin II receptor blocker and a calcium channel blocker in hypertension treatment. J Clin Hypertens 2017, 19(10):983-989
  7. Mahmoudi E, Lu YW, Chang SC, Lin CY, Wang YC, Chang CJ, Cheng MH, Chung KC. Associations of Surgeon and Hospital Volumes with Outcome for Free Tissue Transfer by Using the National Taiwan Population Healthcare Data from 2001-2012. Plastic and Reconstructive Surgery 2017, 140(3):455e-465e
  8. Mahmoudi E, Lu YW, Chang SC, Lin CY, Wang YC, Chang CJ, Cheng MH, Chung KC. The Associations of Hospital Volume, Surgeon Volume, and Surgeon Experience with Complications and 30-day Rehospitalization after Free Tissue Transfer: A National Population Study. Plastic and Reconstructive Surgery 2017, 140(2):403-411
  9. Fife D, Feng Y, Wang MY, Chang CJ, Liu CY, Juang HT, Furnback W, Singh J, Wang B. Epidemiology of pharmaceutically treated depression and treatment resistant depression in Taiwan. Psychiatry Res 2017, 252:277-283
  10. Hsing-Chang Ni, June Hung, Chen-Te Wu, Yu-Yu Wu, Chee-Jen Chang, Rou-Shayn Chen, Ying-Zu Huang. The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum Disorder. Frontiers in Neuroscience 2017, 11:255
  11. Shen-Yen Lin, Sin-Yi Lyu, Ta-Wei Su, Sung-Yu Chu, Chien-Ming Chen, Chien-Fu Hung, Chee-Jen Chang, Po-Jen Ko. Predictive Factors for Additional ProGlide Deployment in Percutaneous Endovascular Aortic Repair. J Vasc Interv Radiol 2017, 28(4):570-575
  12. Yueh-An Lu, Kun-Hua Tu, Cheng-Chia Lee, Patricia W. Wu, Chee-Jen Chang, Ya-Chung Tian, Chih-Wei Yang, Pao-Hsien Chu. Prognostic Impact of Peritonitis in Hemodialysis Patients: A National-wide Longitudinal Study in Taiwan. PLOS ONE 2017, 12(3):e0173710
  13. Jy ming Chiang, Chee Jen Chang, Shen Fu Jiang, Chien Yuh Yeh, Jeng Fu You, Pao Shiu Hsieh, Hsin Yun Huang. Pre-operative serum albumin level substantially predicts post-operative morbidity and mortality among patients with colorectal cancer who undergo elective colectomy. Eur J Cancer Care (Engl) 2017, 26(2). doi: 10.1111/ecc.12403
  14. Hung-Hsueh Chou, Huei-Jean Huang, Hui-Hsin Cheng, Chee-Jen Chang, Lan-Yan Yang, Chu-Chun Huang, Wei-Yang Chang, Swei Hsueh, Angel Chao, Chin-Jung Wang, Yun-Hsin Tang, Cheng-Tao Lin, Jian-Tai Qiu, Min-Yu Chen, Chao-Yu Chen, Kuan-Gen Huang, Tzu-Chun Tsai, Ting-Chang Chang, Chyong-Huey Lai. Self-sampling HPV test in women not undergoing Pap smear for more than 5 years and factors associated with under-screening in Taiwan. Journal of the Formosan Medical Association 2016, 115(12):1089-1096
  15. Huang HY, Li LF, LeeCS, Chang CJ, Chen NH. Outcome and Predictors of Prolonged Mechanical Ventilation in Patients with Heart Failure. Thorac Med 2016, 31(6):311-322
  16. Nan-Kai Wang, Chi-Chun Lai, Jung-Pan Wang, Wei-Chi Wu, Laura Liu, Lung-Kun Yeh, Hsiao-Jung Tseng, Chee-Jen Chang, Fu-Sung Lo, On behalf of the Chang Gung Juvenile Diabetes Eye Study Group. Risk factors associated with the development of retinopathy 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan: a cohort study from the CGJDES. Pediatric Diabetes 2016, 17(6):407-416
  17. Tzu-Chin Lin, Shih-Hsuan Mao, Chih-Hao Chen, Yao-Liang Chen, Ho-Fai Wong, Chee Jen Chang, Yin-Cheng Huang. Systematic Analysis of the Risk Factors Affecting the Recurrence of Traumatic Carotid-Cavernous Sinus Fistula. World Neurosurgery 2016, 90:539-545
  18. Chih-Chen Chang, Yon-Cheong Wong, Cheng-Hsien Wu, Huan-Wu Chen, Li-Jen Wang, Yu-Hsien Lee, Patricia Wanping Wu, Wiwan Irama, Wei Yuan Chen, Chee-Jen Chang. Diagnostic Performance on Low Dose Computed Tomography For Acute Appendicitis Among Attending and Resident Radiologists. Iran J Radiol 2016, 13(2):e33222
  19. Liang-Wen Hang, Jeng-Yuan Hus, Chee-Jen Chang, Hao-Chien Wang, Shih-Lung Cheng, Ching-Hsiung Lin, Ming-Cheng Chan, Chin-Chou Wang, Diahn-Warng Perng, Chong-Jen Yu. Predictive factors warrant screening for obstructive sleep apnea in COPD: a Taiwan National Survey. International Journal of COPD 2016, 11:665-673
  20. Pei-Yeh Chang, Qi Zeng, Kin-Sun Wong, Chao-Jan Wang, Chee-Jen Chang. Chest Wall Constriction after the Nuss Procedure Identified from Chest Radiograph and Multislice Computed Tomography Shortly after Removal of the Bar. Thorac Cardiovasc Surg 2016, 64(1):70-77
  21. Fu-Chih Hsiao, Ying-Chang Tung, Shing-Hsien Chou, Lung-Sheng Wu, Chia-Pin Lin, Chun-Li Wang, Yu-Sheng Lin, Chee-Jen Chang, Pao-Hsien Chu. Fixed-Dose Combinations of Renin-Angiotensin System Inhibitors and Calcium Channel Blockers in the Treatment of Hypertension: A Comparison of Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors. Medicine 2015, 94(51):e2355
  22. Pei-Chun Chen, Ying-Chang Tung, Patricia W. Wu, Lung-Sheng Wu, Yu-Sheng Lin, Chee-Jen Chang, Suefang Kung, Pao-Hsien Chu. Dental Procedures and the Risk of Infective Endocarditis. Medicine 2015, 94(43):1-6
  23. Pei-Yeh Chang, Qi Zeng, Kin-Sun Wong, Jin-Yao Lai, Jeng-Chang Chen, Chao-Jan Wang, Chee-Jen Chang. A Cross-Sectional Study of Chest Wall Development in Patients with Pectus Excavatum. Thorac Cardiovasc Surg 2015, 63(5):433-436
  24. Lin TH, Lai WT, Kuo CT, Hwang JJ, Chiang FT, Chang SC, Chang CJ. Additive effect of in-hospital TIMI bleeding and chronic kidney disease on 1-year cardiovascular events in patients with acute coronary syndrome : Data from Taiwan Acute Coronary Syndrome Full Spectrum Registry. Heart Vessels 2015, 30(4):441-450
  25. Chun-Chieh Wang, Hung-Hsueh Chou, Lan-Yan Yang, Hao Lin, Wen-Shiung Liou, Chih-Wen Tseng, Feng-Yuan Liu, Jui-Der Liou, Kuan-Gen Huang, Huei-Jean Huang, Eng-Yen Huang, Chien-Hsun Chen, Ting-Chang Chang, Chee-Jen Chang, Ji-Hong Hong, Chyong-Huey Lai. A randomized trial comparing concurrent chemoradiotherapy with single-agent cisplatin versus cisplatin plus gemcitabine in patients with advanced cervical cancer: An Asian Gynecologic Oncology Group study. Gynecologic Oncology 2015, 137(3):462-467
  26. Ying-Huang Tsai, Meng-Jer Hsieh, Chee-Jen Chang, Yu-Wen Wen, Han-Chung Hu, Yen-Nan Chao, Yhu-Chering Huang, Cheng-Ta Yang, Chung-Chi Huang. The 23-valent pneumococcal polysaccharide vaccine is effective inelderly adults over 75 years old—Taiwan’s PPV vaccination program. Vaccine 2015, 33(25):2897-2902
  27. Yu-Wen Wen, Hsin Wu, Chee-Jen Chang. Using Dynamic Transmission Modeling to Determine Vaccination Coverage Rate Based on 5-Year Economic Burden of Infectious Disease: An Example of Pneumococcal Vaccine. Value in Health 2015, 6:46-52
  28. Chen-Yu Li, Chia-Pin Lin, Yu-Sheng Lin, Lung-Sheng Wu, Chee-Jen Chang, Pao-Hsien Chu. Newly Diagnosed Atrial Fibrillation Is an Independent Factor for Future Major Adverse Cardiovascular Events. PLOS ONE 2015, 10(4):e0123211
  29. Chen YHLien RITsai SChang CJLai CCChao ANChen KJHwang YSWang NKChen YPChen TLWu WC. Natural history of retinopathy of prematurity: two-year outcomes of a prospective study. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 2015, 35(1):141-148
  30. Ying-Chang Tung, Yu-Sheng Lin, Lung-Sheng Wu, Chee-Jen Chang, Pao-Hsien Chu. Clinical Outcomes and Healthcare Costs in Hypertensive Patients Treated With a Fixed-Dose Combination of Amlodipine/Valsartan. The Journal of Clinical Hypertension 2015, 17(1):51-58
  31. Shu-Hang Ng, Chien-Yu Lin, Sheng-Chieh Chan, Yu-Chun Lin, Tzu-Chen Yen, Chun-Ta Liao, Joseph Tung-Chieh Chang, Sheung-Fat Ko, Hung- Ming Wang, Chee-Jen Chang, Jiun-Jie Wang. Clinical Utility of Multimodality Imaging with Dynamic Contrast-Enhanced MRI, Diffusion-Weighted MRI, and 18F-FDG PET/CT for the Prediction of Neck Control in Oropharyngeal or Hypopharyngeal Squamous Cell Carcinoma Treated with Chemoradiation. PLOS ONE 2014, 9(12): e115933
  32. Shu-Chen Chang, Chee-Jen Chang, Yu-Jr Lin, Ie-Bin Lian, Cathy S. J. Fann. Use of a Failure Probability Constraint to Suggest an Initial Dose in a Phase I Cancer Clinical Trial. Journal of Food and Drug Analysis 2014, 22(4):556-562
  33. Dave W. Chen, Chih-Chien Hu, Yu-Han Chang, Mel S. Lee, Chee-Jen Chang, Pang-Hsin Hsieh. Intra-Articular Bupivacaine Reduces Postoperative Pain and Meperidine Use After Total Hip Arthroplasty: A Randomized, Double-Blind Study. The Journal of Arthroplasty 2014, 29(12):2457-2461
  34. Yun-Chung Cheung, Yu-Ching Lin, Yung-Liang Wan, Kee-Min Yeow, Pei-Chin Huang, Yung-Feng Lo, Hsiu-Pei Tsai, Shir-Hwa Ueng, Chee-Jen Chang. Diagnostic performance of dual-energy contrast-enhanced subtracted mammography in dense breasts compared to mammography alone: interobserver blind-reading analysis. Eur Radiol 2014, 24(10):2394-2403
  35. Chun-Shin Chang, Christopher Glenn Wallace, Yen-Chang Hsiao, Chee-Jen Chang, Philip Kuo-Ting Chen. Botulinum Toxin to Improve Results in Cleft Lip Repair. Plast Reconstr Surg 2014, 134(3):511-516
  36. Wen-Hung Chung, Wan-Chun Chang, Yun-Shien Lee, Ying-Ying Wu, Chih-Hsun Yang, Hsin-Chun Ho, Ming-Jing Chen, Jing-Yi Lin, Rosaline Chung-Yee Hui, Ji-Chen Ho, Wei-Ming Wu, Ting-Jui Chen, Tony Wu, Yih-Ru Wu, Mo-Song Hsih, Po-Hsun Tu, Chen-Nen Chang, Chien-Ning Hsu, Tsu-Lan Wu, Siew-Eng Choon, Chao-Kai Hsu, Der-Yuan Chen, Chin-San Liu, Ching-Yuang Lin, Nahoko Kaniwa, Yoshiro Saito, Yukitoshi Takahashi, Ryosuke Nakamura, Hiroaki Azukizawa, Yongyong Shi, Tzu-Hao Wang, Shiow-Shuh Chuang, Shih-Feng Tsai, Chee-Jen Chang, Yu-Sun Chang, Shuen-Iu Hung. Genetic Variants Associated With Phenytoin-Related Severe Cutaneous Adverse Reactions. JAMA 2014, 312(5):525-534
  37. David Bin-Chia Wu, Craig S. Roberts, Yhu-Chering Huang, Ling Chien, Chi-Hui Fang, Chee Jen Chang. A retrospective study to assess the epidemiological and economic burden of pneumococcal diseases in adults aged 50 years and older in Taiwan. Journal of Medical Economics 2014, 17(5):312-319
  38. Kuan-Yi Wu, Ing-Tsung Hsiao, Cheng-Sheng Chen, Chia-Hsiang Chen, Chia-Ju Hsieh, Yau-Yau Wai, Chee-Jen Chang, Hsiao-Jung Tseng, Tzue-Chen Yen, Chia-Yih Liu, Kun-Ju Lin. Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. Eur J Nucl Med Mol Imaging 2014, 41(4):714-722
  39. Tsung-Hsien Lin, Ho-Tsung Hsin, Chun-Li Wang, Wen-Ter Lai, Ai-Hsien Li, Chi-Tai Kuo, Juey-Jen Hwang, Fu-Tien Chiang, Shu-Chen Chang, Chee-Jen Chang. Impact of impaired glomerular filtration rate and revascularization strategy on one-year cardiovascular events in acute coronary syndrome: data from Taiwan acute coronary syndrome full spectrum registry. BMC Nephrology 2014, 15:66
  40. Kuo-Wei Yeh, Chi-Ming Lee, Chee-Jen Chang, Yu-Jr Lin, Jing-Long Huang. Lipid Profiles Alter from Pro-Atherogenic into Less Atherogenic and Proinflammatory in Juvenile Idiopathic Arthritis Patients Responding to Anti TNF-a Treatment. PLOS ONE 2014, 9(3):e90757
  41. Yu-Sheng Lin, Pi-Hua Liu, Lung-Sheng Wu, Yu-Ming Chen, Chee-Jen Chang, Pao-Hsien Chu. Major adverse cardiovascular events in adult congenital heart disease: a population-based follow-up study from Taiwan. BMC Cardiovascular Disorders 2014, 14:38
  42. Wu LS, Liu PH, Lin YS, Lin CP, Chang CJ, Chu PH. Lupus women with delivery with higher risk of heart failure compared with those without pregnancy but neutral in major adverse cardiovascular events. A population-based matched cohort study. Clinical and experimental rheumatology 2014, 32(1):108-112